lucose degradation products and the peritoneal mesothelium.

Abstract\n stodgy heat-sterilized, glucose-based peritoneal dialysis (PD) fluids contain earthshaking amounts of glucose degradation products (GDPs) such as aldehydes and dicarbonyl compounds (glyoxal, methylglyoxal). These GDPs have been shown to impair carrel functions in various in vitro experimental models. In peritoneal mesothelial cells, GDPs dose-dependently inhibit cell proliferation and intermediary synthesis. In addition, some GDPs strongly promote generation of mature glycation end-products ( be ons). Immunohistochemistry finds AGEs in the peritoneal membrane of chronic continuous ambulant peritoneal dialysis (CAPD) patients, suggesting that peritoneal AGE accumulation may be involved in chronicperitoneal fibrosis. The makeup of GDPs might be prevented by filter-sterilization of PD fluids. Another excerpt is to separate the glucose and the buffer clay in dual-chambered or multi-chambered containers. In these systems, the glucose is kept in a separate compartment a t spunky concentration and very broken in pH-both conditions being known to calumniate the degree of glucose decomposition during autoclaving. initial experimental evidence suggests that these novel, multi-chambered fluids importantly improve in vitro biocompatibility; however, the clinical relevance of these results remains to be established in clinical trials.If you want to get a full essay, order it on our website:

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